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Confirmed Plenary Speakers (to Date) |
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Sunday April 23, 2023 |
17:30 | Registration |
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19:30 | Dinner at the Hotel |
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21:00 | Get Together at the Castle Bar |
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Monday April 24, 2023 |
07:15 | Breakfast |
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Opening |
08:15 | Opening Ceremony |
Prof. Laura HEITMAN (UNIVERSITY OF LEIDEN, Leiden, The Netherlands) |
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Session 1: Introduction to Small Molecule Degraders: PROTACS and Molecular Glues |
08:30 | Introduction to Small Molecule Degraders: PROTACS and Molecular Glues - Part 1 |
Prof. Alessio CIULLI (UNIVERSITY OF DUNDEE, Dundee, United Kingdom) Dr Suzanne O'CONNOR (UNIVERSITY OF DUNDEE, Dundee, United Kingdom) |
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10:30 | Introduction to Small Molecule Degraders: PROTACS and Molecular Glues - Part 2 |
Prof. Alessio CIULLI (UNIVERSITY OF DUNDEE, Dundee, United Kingdom) Dr Suzanne O'CONNOR (UNIVERSITY OF DUNDEE, Dundee, United Kingdom) |
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10:00 | Coffee Break |
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12:00 | Lunch |
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Session 2: The Ternary Complex E3-Degrader-Target: Biophysical Binding Assays and Structures |
13:30 | The Ternary Complex E3-Degrader-Target: Biophysical Binding Assays and Structures - Part 1 |
Dr Chun-wa CHUNG (GLAXOSMITHKLINE, Stevenage, United Kingdom) |
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15:30 | The Ternary Complex E3-Degrader-Target: Biophysical Binding Assays and Structures - Part 2 |
Dr Chun-wa CHUNG (GLAXOSMITHKLINE, Stevenage, United Kingdom) |
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15:00 | Coffee Break |
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17:00 | Day End |
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18:00 | Walking Tour through Leiden |
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19:30 | Dinner in Leiden |
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Tuesday April 25, 2023 |
Session 3: Degrader Probes & Protein Degraders |
08:30 | Quality Criteria for Degrader Probes |
Dr Ingo HARTUNG (MERCK HEALTHCARE, Darmstadt, Germany) |
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10:30 | Clinical Aspects of Small Molecule Protein Degraders |
Dr Ingo HARTUNG (MERCK HEALTHCARE, Darmstadt, Germany) |
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10:00 | Coffee Break |
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12:00 | Lunch |
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Session 4: Medicinal Chemistry Optimisation of Small Molecule Degraders |
13:30 | Medicinal Chemistry Optimisation of Small Molecule Degraders - Part 1 |
Dr Andrea TESTA (AMPHISTA THERAPEUTICS, Cambridge, United Kingdom) |
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15:30 | Medicinal Chemistry Optimisation of Small Molecule Degraders - Part 2 |
Dr Andrea TESTA (AMPHISTA THERAPEUTICS, Cambridge, United Kingdom) |
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15:00 | Coffee Break |
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17:00 | Day End |
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19:30 | Dinner at the hotel |
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21:00 | Get Together at the Castle Bar |
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Wednesday April 26, 2023 |
07:00 | Breakfast |
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Session 5: Importance of Cellular Degradation Kinetics and Mechanisms for Development of Potent Therapeutic Degraders |
08:30 | Importance of Cellular Degradation Kinetics and Mechanisms for Development of Potent Therapeutic Degraders - Part 1 |
Dr Danette DANIELS (FOGHORN THERAPEUTICS, Cambridge, United States) |
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10:30 | Importance of Cellular Degradation Kinetics and Mechanisms for Development of Potent Therapeutic Degraders - Part 2 |
Dr Danette DANIELS (FOGHORN THERAPEUTICS, Cambridge, United States) |
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10:00 | Coffee Break |
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12:00 | Wrap up and Lunch |
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